Product Name:

NebuSelect™ Recombinant Human IL-7

Catalog#:

NBL-240501

Description:

NebuSelect™ Recombinant Human IL-7(Cat#NBL-240501) is expressed in E.coli with tag free. It contains Asp26-His177. This recombinant protein is of high purity, verified to be greater than 95% by SDS-PAGE. Endotoxin levels are less than 1 EU/µg, as determined by the LAL (Limulus Amebocyte Lysate) assay.

Species:

Human

Expression System:

E.coli

Molecular Weight: 

The protein has a predicted MW of 17.5 kDa same as Bis-Tris PAGE result.

Target Name:

IL-7

Target Information:

Interleukin (IL)-7 is a non-redundant cytokine in T-cell development and function. It is required in early T-cell development as well as for T-cell homeostasis and is secreted by stromal cells in the thymic and bone marrow (BM) environment. IL-7 binds to its receptor which is composed of the two chains IL-7Rα (CD127), shared with the thymic stromal lymphopoietin (TSLP), and the common γ chain (CD132) for IL-2, IL-15, IL-9 and IL-21. Whereas γc is expressed by most hematopoietic cells, IL-7Rα is nearly exclusively expressed on lymphoid cells. After binding to its receptor, IL-7 signals through two different pathways: Jak-Stat (Janus kinase-Signal transducer and activator of transcription) and PI3K/Akt responsible for differentiation and survival, respectively.

Amino Acid Sequence: 

Asp26-His177

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1 EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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